Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.43 |
| ▸ | PIM1 | P11309 | 4/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5798034 | 0.98 | KDM4E (0.45) | KDM4EMAPTNPSR1KMT2AMEN1 | |
| SCHEMBL5775242 | 0.94 | NPY5R (0.49) | KDM4EMAPTNPSR1KMT2AMEN1 | |
| SCHEMBL7961165 | 0.87 | NPY5R (0.56) | KDM4EMAPTNPSR1KMT2AMEN1 | |
| SCHEMBL5771952 | 0.87 | KMT2A (0.45) | KMT2AALDH1A1POLBNPY5RSYK | |
| SCHEMBL5773349 | 0.85 | NPY5R (0.52) | KDM4EKMT2AL3MBTL1NPY5R | |
| SCHEMBL5771896 | 0.85 | NPY5R (0.52) | KDM4EKMT2AL3MBTL1NPY5R | |
| Hydrochloric Acid SCHEMBL5773755 | 0.85 | NPY5R (0.54) | KDM4EMAPTNPSR1KMT2AMEN1 | |
| SCHEMBL5773681 | 0.84 | NPY5R (0.54) | KDM4EKMT2AL3MBTL1NPY5R | |
| Hydrochloric Acid SCHEMBL5777287 | 0.83 | NPY5R (0.50) | KDM4EKMT2AL3MBTL1NPY5R | |
| Hydrochloric Acid SCHEMBL5776807 | 0.83 | NPY5R (0.50) | KDM4EKMT2AL3MBTL1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | claimed |
| EP-1054887-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2000-11-29 | — | — | EP | claimed |
| WO-1999040091-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 1999-08-12 | — | — | WO | claimed |