Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SPR | P35270 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961437 | 0.83 | DPP4 (0.48) | ALDH1A1NOTUMCYP3A4MAPK1DPP4 | |
| SCHEMBL1313390 | 0.81 | ALDH1A1 (0.61) | ALDH1A1NOTUMCYP3A4MAPK1DPP4 | |
| Hydrochloric Acid SCHEMBL7961279 | 0.81 | DPP4 (0.47) | ALDH1A1NOTUMCYP3A4MAPK1DPP4 | |
| SCHEMBL9197919 | 0.76 | ALDH1A1 (0.48) | ALDH1A1NOTUMCYP3A4MAPK1DPP4 | |
| SCHEMBL34467595 | 0.75 | ALDH1A1 (0.41) | ALDH1A1MAPK1TSHR | |
| SCHEMBL27630874 | 0.74 | ALDH1A1 (0.46) | ALDH1A1CYP3A4MAPK1DPP4TSHR | |
| SCHEMBL15616798 | 0.74 | ALDH1A1 (0.71) | ALDH1A1CYP3A4TSHRGAA | |
| SCHEMBL7744335 | 0.74 | ALDH1A1 (0.46) | ALDH1A1NOTUMCYP3A4MAPK1DPP4 | |
| SCHEMBL30949575 | 0.72 | MAPK1 (0.43) | ALDH1A1MAPK1TSHRTTRGAA | |
| SCHEMBL28669965 | 0.70 | ALDH1A1 (0.37) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211189-B1 | NITRIC OXIDE SYNTHASE INHIBITORS; ANTIINFLAMMATORY AGENTS, ANALGESICS | ASTRAZENECA UK LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| US-6083952-A | Compounds | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-07-04 | — | — | US | disclosed |
| EP-1000064-A1 | COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999001455-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-01-14 | — | — | WO | disclosed |