Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAPDH | P04406 | 1/20 | 0.45 |
| ▸ | TYMP | P19971 | 9/20 | 0.44 |
| ▸ | HRAS | P01112 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | EIF4E | P06730 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TOP1 | P11387 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618793 | 0.94 | TYMP (0.47) | GAPDHTYMPHRASLMNASMN1; SMN2 | |
| SCHEMBL7961309 | 0.89 | CA1 (0.38) | GAPDHTYMPHRASCA1CA2 | |
| SCHEMBL13130114 | 0.85 | TYMP (0.57) | TYMPLMNASMN1; SMN2ALDH1A1GLA | |
| SCHEMBL7974829 | 0.85 | TYMP (0.57) | TYMPLMNASMN1; SMN2ALDH1A1GLA | |
| SCHEMBL13130110 | 0.85 | TYMP (0.47) | TYMPLMNASMN1; SMN2ALDH1A1GLA | |
| SCHEMBL13130121 | 0.85 | TYMP (0.57) | TYMPLMNASMN1; SMN2ALDH1A1GLA | |
| SCHEMBL13130125 | 0.85 | TYMP (0.47) | TYMPLMNASMN1; SMN2ALDH1A1GLA | |
| SCHEMBL12300349 | 0.85 | LMNA (0.47) | GAPDHHRASCA1CA2CA9 | |
| SCHEMBL6912407 | 0.81 | LMNA (0.47) | GAPDHHRASCA1CA2CA9 | |
| SCHEMBL12300734 | 0.81 | LMNA (0.48) | GAPDHHRASCA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281201-B1 | REPLACEMENT OF THE ADENINE MOIETY IN THE (2'-5')OLIGOADENYLATE TRIMER CORE WITH 1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE OR WITH N6-(BENZYLAMINO)PURINE (ADEBN)-MOIETIES HAS RESULTED IN A NEW GROUP OF INHIBITORS OF HIV-1 REPLICATION. | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2001-08-28 | — | — | US | disclosed |
| WO-1998056385-A1 | BASE-MODIFIED DERIVATIVES OF 2',5'-OLIGOADENYLATE AND ANTIVIRAL USES THEREOF | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 1998-12-17 | — | — | WO | disclosed |