Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | EIF4E | P06730 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TOP1 | P11387 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GAPDH | P04406 | 2/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12151509 | 0.92 | LMNA (0.45) | LMNASMN1; SMN2ALDH1A1GLAEIF4E | |
| SCHEMBL6912407 | 0.90 | LMNA (0.47) | LMNASMN1; SMN2ALDH1A1GLAEIF4E | |
| SCHEMBL12300734 | 0.90 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1GLAEIF4E | |
| SCHEMBL6912924 | 0.89 | LMNA (0.57) | LMNASMN1; SMN2ALDH1A1GLAEIF4E | |
| SCHEMBL6912376 | 0.88 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1GLAEIF4E | |
| SCHEMBL12300344 | 0.87 | LMNA (0.45) | LMNASMN1; SMN2ALDH1A1GLAEIF4E | |
| SCHEMBL7961312 | 0.85 | GAPDH (0.45) | LMNASMN1; SMN2ALDH1A1GLAEIF4E | |
| SCHEMBL12300346 | 0.85 | LMNA (0.43) | LMNASMN1; SMN2ALDH1A1GLAEIF4E | |
| SCHEMBL12150476 | 0.84 | LMNA (0.54) | LMNASMN1; SMN2ALDH1A1GLAEIF4E | |
| SCHEMBL7042701 | 0.84 | MEN1 (0.59) | LMNASMN1; SMN2ALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022083-B2 | Antiviral phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2011-09-20 | — | — | US | disclosed |
| US-7452901-B2 | Anti-cancer phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2008-11-18 | — | — | US | disclosed |
| US-7429565-B2 | Antiviral phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2008-09-30 | — | — | US | disclosed |