Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.32 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | KDM6B | O15054 | 1/20 | 0.30 |
| ▸ | KDM4A | O75164 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960325 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2HPGDKDM4EALDH1A1MAPT | |
| SCHEMBL7952517 | 0.73 | SMN1; SMN2 (0.44) | SMN1; SMN2HPGDKDM4EGAA | |
| SCHEMBL7952144 | 0.73 | SMN1; SMN2 (0.44) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL7951873 | 0.73 | SMN1; SMN2 (0.47) | SMN1; SMN2HPGDKMT2AALDH1A1MAPT | |
| SCHEMBL7961707 | 0.72 | SMN1; SMN2 (0.46) | SMN1; SMN2 | |
| SCHEMBL10272980 | 0.72 | GAA (0.47) | SMN1; SMN2HPGDMEN1KMT2AKDM4E | |
| SCHEMBL22683855 | 0.72 | GAA (0.44) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL7951898 | 0.70 | SMN1; SMN2 (0.47) | SMN1; SMN2HPGDMEN1KMT2AKDM4E | |
| SCHEMBL7963508 | 0.69 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL5544959 | 0.67 | SMN1; SMN2 (0.65) | SMN1; SMN2HPGDKDM4EALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211189-B1 | NITRIC OXIDE SYNTHASE INHIBITORS; ANTIINFLAMMATORY AGENTS, ANALGESICS | ASTRAZENECA UK LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| US-6083952-A | Compounds | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-07-04 | — | — | US | disclosed |
| EP-1000064-A1 | COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999001455-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-01-14 | — | — | WO | disclosed |