Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | F2R | P25116 | 1/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7952517 | 0.84 | SMN1; SMN2 (0.44) | SMN1; SMN2HPGDLMNAHTTTSHR | |
| SCHEMBL7961935 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL7960325 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2HPGDALDH1A1LMNAMAPT | |
| SCHEMBL7962014 | 0.73 | SMN1; SMN2 (0.44) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL7961707 | 0.72 | SMN1; SMN2 (0.46) | SMN1; SMN2 | |
| SCHEMBL7951873 | 0.70 | SMN1; SMN2 (0.47) | SMN1; SMN2HPGDKMT2AALDH1A1LMNA | |
| SCHEMBL7963508 | 0.69 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AALDH1A1GAANPSR1 | |
| SCHEMBL18354481 | 0.69 | ERN1 (0.57) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL7951898 | 0.68 | SMN1; SMN2 (0.47) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL5544959 | 0.67 | SMN1; SMN2 (0.65) | SMN1; SMN2HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211189-B1 | NITRIC OXIDE SYNTHASE INHIBITORS; ANTIINFLAMMATORY AGENTS, ANALGESICS | ASTRAZENECA UK LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| CN-1268138-A | Compounds | ASTRA PHARMA PROD (GB) | 2000-09-27 | — | — | CN | disclosed |
| US-6083952-A | Compounds | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-07-04 | — | — | US | disclosed |
| EP-1000064-A1 | COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999001455-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-01-14 | — | — | WO | disclosed |