Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | F2R | P25116 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7951873 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2HPGDNPC1GLAKMT2A | |
| SCHEMBL7952517 | 0.73 | SMN1; SMN2 (0.44) | SMN1; SMN2HPGDNPC1KDM4EP2RX7 | |
| SCHEMBL7962014 | 0.70 | SMN1; SMN2 (0.44) | SMN1; SMN2HPGDMEN1KMT2AKDM4E | |
| SCHEMBL7960224 | 0.70 | SMN1; SMN2 (0.47) | SMN1; SMN2HPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL5544959 | 0.70 | SMN1; SMN2 (0.65) | SMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL7964391 | 0.66 | SMN1; SMN2 (0.51) | SMN1; SMN2HPGDNPC1GLAMEN1 | |
| SCHEMBL7446407 | 0.65 | HPGD (0.69) | SMN1; SMN2HPGDNPC1GLAMEN1 | |
| SCHEMBL9939750 | 0.65 | SMN1; SMN2 (0.57) | SMN1; SMN2 | |
| SCHEMBL696250 | 0.65 | ALDH1A1 (0.52) | HPGDNPC1GLAKMT2AKDM4E | |
| SCHEMBL2844436 | 0.65 | ALDH1A1 (0.71) | HPGDNPC1GLAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211189-B1 | NITRIC OXIDE SYNTHASE INHIBITORS; ANTIINFLAMMATORY AGENTS, ANALGESICS | ASTRAZENECA UK LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| US-6083952-A | Compounds | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-07-04 | — | — | US | disclosed |
| EP-1000064-A1 | COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999001455-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-01-14 | — | — | WO | disclosed |