Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5825529 | 0.92 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1RAB9ANPC1KMT2A | |
| SCHEMBL9011867 | 0.90 | SMN1; SMN2 (0.59) | SMN1; SMN2L3MBTL1RAB9ANPC1KMT2A | |
| SCHEMBL9011659 | 0.88 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1RAB9ANPC1KMT2A | |
| SCHEMBL9011602 | 0.88 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1RAB9ANPC1KMT2A | |
| SCHEMBL891407 | 0.87 | SMN1; SMN2 (0.61) | SMN1; SMN2L3MBTL1RAB9ANPC1KMT2A | |
| SCHEMBL12428 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1RAB9ANPC1KMT2A | |
| SCHEMBL9011759 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1RAB9ANPC1KMT2A | |
| SCHEMBL6110605 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2L3MBTL1RAB9ANPC1KMT2A | |
| SCHEMBL14956919 | 0.82 | ALDH1A1 (0.55) | SMN1; SMN2L3MBTL1RAB9ANPC1KMT2A | |
| SCHEMBL11963241 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2L3MBTL1RAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006082-A2 | TREATMENT OF ANXIETY DISORDERS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |