Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962056 | 0.92 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1KMT2ANPC1RAB9A | |
| SCHEMBL891407 | 0.87 | SMN1; SMN2 (0.61) | SMN1; SMN2L3MBTL1KMT2ANPC1RAB9A | |
| SCHEMBL9011867 | 0.85 | SMN1; SMN2 (0.59) | SMN1; SMN2L3MBTL1KMT2ANPC1RAB9A | |
| SCHEMBL9011602 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1KMT2ANPC1RAB9A | |
| SCHEMBL9011659 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1KMT2ANPC1RAB9A | |
| SCHEMBL11790 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2L3MBTL1KMT2ANPC1RAB9A | |
| SCHEMBL8640378 | 0.82 | HTR1A (0.63) | SMN1; SMN2L3MBTL1KMT2ANPC1RAB9A | |
| SCHEMBL9248777 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1KMT2ANPC1RAB9A | |
| SCHEMBL15086526 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1KMT2ANPC1RAB9A | |
| SCHEMBL12428 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111039929-A | Antitumor compound NY and series derivatives thereof | 中国人民解放军北部战区总医院 | 2020-04-21 | — | — | CN | disclosed |
| US-8927224-B2 | Fluorescent ion indicators and their applications | AAT BIOQUEST, INC. (US) | 2015-01-06 | — | — | US | disclosed |
| US-8779165-B2 | Fluorescent ion indicators and their applications | AAT BIOQUEST, INC. (US) | 2014-07-15 | — | — | US | disclosed |
| US-20140080170-A1 | FLUORESCENT ION INDICATORS AND THEIR APPLICATIONS | AAT BIOQUEST, INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-7135466-B2 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-14 | — | — | US | disclosed |
| US-20060211717-A1 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-09-21 | — | — | US | disclosed |
| US-20040132727-A1 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN HOLDINGS KABUSHIKI KAISHA (JP) | 2004-07-08 | — | — | US | disclosed |
| EP-1243582-A1 | QUINOLINE AND QUINAZOLINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2002-09-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211717-A1 | Quinoline and quinazoline derivatives and drugs containing the same | PDGFRA, PDGFRB, PDGFA | SMN1; SMN2 4616/4885L3MBTL1 1545/4885KMT2A 2022/4885 |
| US-20040132727-A1 | Quinoline and quinazoline derivatives and drugs containing the same | PDGFRA, PDGFRB, PDGFA | SMN1; SMN2 4780/4885L3MBTL1 1895/4885KMT2A 2006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.