Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964875 | 0.90 | CYP11B2 (0.37) | CYP11B2TDP1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL7963509 | 0.87 | CFTR (0.40) | CYP11B2TDP1ALDH1A1CYP2C9ABL1 | |
| SCHEMBL7964582 | 0.84 | CYP11B2 (0.43) | CYP11B2MKNK1MKNK2ALDH1A1KCNH2 | |
| SCHEMBL2158122 | 0.84 | CYP11B2 (0.43) | CYP11B2MKNK1MKNK2ALDH1A1KCNH2 | |
| SCHEMBL7964580 | 0.84 | CYP11B2 (0.43) | CYP11B2MKNK1MKNK2ALDH1A1KCNH2 | |
| SCHEMBL7964715 | 0.84 | CYP11B2 (0.43) | CYP11B2TDP1MKNK1MKNK2ALDH1A1 | |
| SCHEMBL7963297 | 0.82 | MKNK1 (0.42) | CYP11B2MKNK1MKNK2ALDH1A1CSNK1D | |
| SCHEMBL7961681 | 0.81 | CYP11B2 (0.37) | CYP11B2TDP1ALDH1A1P2RX7 | |
| SCHEMBL7962948 | 0.81 | PLAU (0.35) | MKNK1MKNK2LMNAABL1PDK2 | |
| SCHEMBL7955168 | 0.80 | CSNK1D (0.39) | CYP11B2MKNK1MKNK2P2RX7CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | claimed |
| EP-0946555-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Aventis Pharma S.A. (FR) | 1999-10-06 | — | — | EP | claimed |
| WO-1998025925-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1998-06-18 | — | — | WO | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |