Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964875 | 0.89 | CYP11B2 (0.37) | ABL1ALDH1A1TDP1HCRTR1CYP11B2 | |
| SCHEMBL7962238 | 0.87 | CYP11B2 (0.41) | ABL1ALDH1A1TDP1CYP2C9CYP11B2 | |
| SCHEMBL7964717 | 0.86 | ALDH1A1 (0.40) | MEN1KMT2AALDH1A1TDP1NR4A2 | |
| SCHEMBL7952536 | 0.85 | ALDH1A1 (0.40) | MEN1KMT2AALDH1A1NR4A2GABRA1 | |
| SCHEMBL7962101 | 0.85 | NR4A2 (0.40) | ABL1MEN1KMT2AALDH1A1NR4A2 | |
| SCHEMBL7967855 | 0.83 | UCHL1 (0.40) | MEN1KMT2AALDH1A1TDP1GABRA1 | |
| SCHEMBL7965416 | 0.82 | ABL1 (0.37) | ABL1MEN1KMT2AHCRTR1HTR2C | |
| SCHEMBL7963301 | 0.81 | HCRTR1 (0.34) | MEN1KMT2AALDH1A1HCRTR1 | |
| SCHEMBL7961681 | 0.79 | CYP11B2 (0.37) | KMT2AALDH1A1TDP1CYP11B1CYP11B2 | |
| SCHEMBL8328648 | 0.78 | KDM4E (0.38) | KMT2AALDH1A1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |