Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.81 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | NAMPT | P43490 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21987079 | 0.97 | POLB (0.81) | POLBSLC6A7SMN1; SMN2AKR1C3CYP2C9 | |
| SCHEMBL22394625 | 0.91 | SLC6A7 (0.70) | POLBSLC6A7CYP2C9CYP2C19MEN1 | |
| SCHEMBL7961639 | 0.90 | SMN1; SMN2 (0.70) | POLBSLC6A7SMN1; SMN2AKR1C3CYP2C9 | |
| SCHEMBL3573771 | 0.89 | SLC6A7 (0.81) | POLBSLC6A7SMN1; SMN2AKR1C3CYP2C9 | |
| SCHEMBL4378294 | 0.85 | SMN1; SMN2 (0.59) | POLBSLC6A7SMN1; SMN2AKR1C3CYP2C9 | |
| SCHEMBL21987021 | 0.85 | ALDH1A1 (0.64) | POLBSMN1; SMN2AKR1C3MEN1KMT2A | |
| SCHEMBL3640637 | 0.85 | GRM5 (0.63) | POLBSLC6A7SMN1; SMN2AKR1C3CYP2C9 | |
| SCHEMBL8595777 | 0.83 | POLB (0.87) | POLBSLC6A7MEN1KMT2AALDH1A1 | |
| SCHEMBL10721777 | 0.83 | MEN1 (0.87) | POLBSLC6A7MEN1KMT2AALDH1A1 | |
| SCHEMBL7956657 | 0.82 | SMN1; SMN2 (0.67) | POLBSLC6A7SMN1; SMN2AKR1C3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |