Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 13/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7206601 | 0.85 | MTNR1A (0.56) | MTNR1ACYP2C19NPSR1MAPTPOLB | |
| SCHEMBL7201190 | 0.77 | ITGB2 (0.33) | MTNR1AMTNR1BHSD17B10HPGDKDM4E | |
| SCHEMBL7201840 | 0.74 | ITGB2 (0.33) | — | |
| SCHEMBL7199997 | 0.74 | ITGB2 (0.33) | — | |
| SCHEMBL6075347 | 0.72 | MTNR1A (0.71) | MTNR1AMAPTGAAMTNR1B | |
| SCHEMBL7522254 | 0.71 | MTNR1A (1.00) | MTNR1ANAMPTMTNR1BKDM4E | |
| SCHEMBL6076320 | 0.69 | MTNR1A (0.59) | MTNR1AMAPT | |
| SCHEMBL7201065 | 0.69 | MTNR1A (1.00) | MTNR1AMAPTGAA | |
| SCHEMBL5343915 | 0.69 | MTNR1A (0.52) | MTNR1ACYP1A2CYP2C19NPSR1MAPT | |
| SCHEMBL7200002 | 0.68 | ADRA2A (0.33) | MTNR1ACYP1A2CYP2C19NPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313160-B1 | FOR THERAPY AND PROPHYLAXIS OF MELATONINERGIC DISORDERS | ADIR ET COMPAGNIE (FR) | 2001-11-06 | — | — | US | disclosed |