Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | NAAA | Q02083 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.40 |
| ▸ | AGXT | P21549 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL281251 | 0.98 | TSHR (0.58) | TSHRTDP1L3MBTL1HRH4HRH3 | |
| SCHEMBL5857276 | 0.92 | L3MBTL1 (0.53) | TSHRTDP1L3MBTL1HRH4HRH3 | |
| SCHEMBL716935 | 0.92 | TSHR (0.56) | TSHRTDP1L3MBTL1HRH4HRH3 | |
| SCHEMBL517888 | 0.90 | L3MBTL1 (0.54) | TSHRTDP1L3MBTL1HRH4HRH3 | |
| SCHEMBL580258 | 0.90 | L3MBTL1 (0.54) | TSHRTDP1L3MBTL1HRH4HRH3 | |
| SCHEMBL5619569 | 0.90 | L3MBTL1 (0.54) | TSHRTDP1L3MBTL1HRH4HRH3 | |
| SCHEMBL850609 | 0.90 | L3MBTL1 (0.54) | TSHRTDP1L3MBTL1HRH4HRH3 | |
| SCHEMBL31490075 | 0.90 | L3MBTL1 (0.54) | TSHRTDP1L3MBTL1HRH4HRH3 | |
| SCHEMBL4229986 | 0.90 | L3MBTL1 (0.54) | TSHRTDP1L3MBTL1HRH4HRH3 | |
| SCHEMBL7564811 | 0.90 | L3MBTL1 (0.54) | TSHRTDP1L3MBTL1HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271238-B1 | USEFUL IN TREATING AND PREVENTING DISEASES INVOLVING CHYMOTRYPSIN TYPE PROTEASES WHICH ARE RELATED TO ASTHMA, ALLERGY, INFLAMMATIONS, RHEUMATISM, HYPERTENSION, HEART FAILURE, MYOCARDIAL INFARCTION, AND CARDIAC HYPERTROPHY | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-08-07 | — | — | US | disclosed |
| EP-0936216-A1 | NOVEL ACETAMIDE DERIVATIVES AND PROTEASE INHIBITORS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1999-08-18 | — | — | EP | disclosed |