Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.52 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | RAD52 | P43351 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953344 | 0.92 | KDM4E (0.53) | MAPTL3MBTL1KDM4EPRMT5WDR77 | |
| SCHEMBL7969553 | 0.90 | L3MBTL1 (0.55) | L3MBTL1KDM4EPRMT5WDR77SMN1; SMN2 | |
| SCHEMBL7200720 | 0.88 | SMN1; SMN2 (0.57) | MAPTKDM4EPRMT5WDR77MAPK1 | |
| SCHEMBL27193282 | 0.88 | SMN1; SMN2 (0.57) | MAPTKDM4EPRMT5WDR77MAPK1 | |
| SCHEMBL7962210 | 0.87 | TP53 (0.56) | TP53MAPTL3MBTL1KDM4EPRMT5 | |
| SCHEMBL7969477 | 0.87 | MAPT (0.50) | MAPTL3MBTL1KDM4EPRMT5WDR77 | |
| SCHEMBL7953962 | 0.87 | ABCB1 (0.54) | TP53MAPTL3MBTL1KDM4EMAPK1 | |
| SCHEMBL7966950 | 0.87 | TSHR (0.56) | MAPTL3MBTL1KDM4EPRMT5WDR77 | |
| SCHEMBL7969310 | 0.87 | L3MBTL1 (0.51) | L3MBTL1KDM4EPRMT5WDR77SMN1; SMN2 | |
| SCHEMBL7962982 | 0.86 | SMN1; SMN2 (0.49) | MAPTL3MBTL1KDM4EPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |