Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963018 | 0.87 | TP53 (0.56) | TP53MAPTL3MBTL1KDM4EGAA | |
| SCHEMBL7962698 | 0.83 | L3MBTL1 (0.46) | L3MBTL1KDM4EGAAMAPK1SMN1; SMN2 | |
| SCHEMBL7962746 | 0.83 | SMN1; SMN2 (0.47) | MAPTL3MBTL1KDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL7962212 | 0.82 | ALDH1A1 (0.41) | TP53MAPTKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL7962207 | 0.82 | ALDH1A1 (0.43) | TP53MAPTL3MBTL1KDM4EMAPK1 | |
| SCHEMBL7953344 | 0.79 | KDM4E (0.53) | MAPTL3MBTL1KDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL7965117 | 0.79 | CYP1A2 (0.58) | TP53MAPTGAASMN1; SMN2MEN1 | |
| Sulfuric Acid SCHEMBL7968960 | 0.78 | ADORA2A (0.39) | KDM4EGAASMN1; SMN2PRMT5WDR77 | |
| SCHEMBL7963395 | 0.77 | LMNA (0.44) | TP53MAPTKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL7969553 | 0.76 | L3MBTL1 (0.55) | L3MBTL1KDM4ESMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |