Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7219997 | 0.77 | CYP19A1 (0.45) | KDM4EALDH1A1L3MBTL1FFAR1MBOAT4 | |
| SCHEMBL1042523 | 0.77 | KDM4E (0.40) | EGLN2KDM4EALDH1A1L3MBTL1FFAR1 | |
| SCHEMBL22578745 | 0.77 | KDM4E (0.39) | EGLN2KDM4EALDH1A1L3MBTL1MBOAT4 | |
| SCHEMBL8569361 | 0.77 | FFAR1 (0.41) | KDM4EALDH1A1L3MBTL1FFAR1MBOAT4 | |
| SCHEMBL27576276 | 0.77 | KDM4E (0.40) | EGLN2KDM4EALDH1A1L3MBTL1FFAR1 | |
| SCHEMBL24168720 | 0.76 | KDM4E (0.37) | KDM4EALDH1A1L3MBTL1CACNA1HCACNA1G | |
| SCHEMBL13738243 | 0.75 | CCNC (0.37) | EGLN2KDM4ECYP3A4MBOAT4KCNH2 | |
| SCHEMBL7213728 | 0.74 | KDM4E (0.49) | KDM4EALDH1A1L3MBTL1FFAR1MBOAT4 | |
| SCHEMBL27303610 | 0.73 | AR (0.41) | EGLN2KDM4EALDH1A1L3MBTL1CACNA1H | |
| SCHEMBL19189339 | 0.73 | CA12 (0.37) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616465-B1 | TRIAZINE-OXADIAZOLES | NOVARTIS AG (CH) | 2015-11-04 | — | — | EP | disclosed |
| US-20150025057-A1 | Triazine-oxadiazoles | NOVARTIS AG (CH) | 2015-01-22 | — | — | US | disclosed |
| US-8895733-B2 | Triazine-oxadiazoles | NOVARTIS AG (CH) | 2014-11-25 | — | — | US | disclosed |
| US-20140051676-A1 | Triazine-oxadiazoles | NOVARTIS AG (CH) | 2014-02-20 | — | — | US | disclosed |
| EP-2616465-A1 | TRIAZINE-OXADIAZOLES | Novartis AG (CH) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035023-A1 | TRIAZINE-OXADIAZOLES | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150025057-A1 | Triazine-oxadiazoles | OPRK1, OPRD1, OPRL1 | EGLN2 738/4885KDM4E 3067/4885ALDH1A1 439/4885 |
| US-20140051676-A1 | Triazine-oxadiazoles | OPRK1, OPRD1, OPRL1 | EGLN2 738/4885KDM4E 3067/4885ALDH1A1 439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.