Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4568014 | 0.88 | SMN1; SMN2 (0.41) | KMT2ANPSR1ALDH1A1F10SMN1; SMN2 | |
| SCHEMBL4568377 | 0.87 | KMT2A (0.39) | KMT2ANPSR1ALDH1A1F10SMN1; SMN2 | |
| SCHEMBL5241843 | 0.87 | AKR1C3 (0.48) | KMT2ANPSR1ALDH1A1F10SMN1; SMN2 | |
| SCHEMBL4568024 | 0.87 | ABCB1 (0.39) | KMT2ANPSR1ALDH1A1F10SMN1; SMN2 | |
| SCHEMBL17233418 | 0.85 | KMT2A (0.41) | KMT2ANPSR1ALDH1A1F10SMN1; SMN2 | |
| SCHEMBL14628609 | 0.85 | KMT2A (0.41) | KMT2ANPSR1ALDH1A1F10SMN1; SMN2 | |
| SCHEMBL4568373 | 0.85 | KMT2A (0.44) | KMT2ANPSR1ALDH1A1F10SMN1; SMN2 | |
| SCHEMBL7953132 | 0.85 | CYP1A2 (0.44) | NPSR1ALDH1A1SMN1; SMN2TP53CYP3A4 | |
| SCHEMBL4568019 | 0.84 | MTNR1B (0.40) | KMT2ANPSR1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4568371 | 0.84 | TAS1R3 (0.39) | KMT2ANPSR1ALDH1A1F10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6252084-B1 | THERAPY FOR SEPSIS SHOCK | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0620215-B1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | LILLY CO ELI (US) | 1999-08-18 | — | — | EP | disclosed |
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0620215-A1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |