Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | NOS3 | P29474 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3032709 | 0.81 | HDAC1 (0.64) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL3036988 | 0.80 | HDAC1 (0.62) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL10324743 | 0.78 | KMT2A (0.67) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL1248895 | 0.77 | MAPK1 (0.61) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL8218590 | 0.77 | NPC1 (0.71) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL13210596 | 0.76 | HIF1A (0.72) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL3961413 | 0.76 | KMT2A (0.67) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL8162947 | 0.75 | HIF1A (0.72) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL18774048 | 0.75 | NPC1 (0.75) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL15676737 | 0.75 | L3MBTL1 (0.66) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310211-B1 | ANTI-VIRAL ACTIVITY AGAINST HERPES VIRUS, CYTOMEGALOVIRUS. MANY OF THESE COMPOUNDS ARE ALSO ACTIVE AGAINST VARICELLA ZOSTER VIRUS, EPSTEIN-BARR VIRUS, HERPES SIMPLEX VIRUS AND HUMAN HERPES VIRUS TYPE 8 | PHARMACIA & UPJOHN COMPANY | 2001-10-30 | — | — | US | disclosed |