Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.70 |
| ▸ | NPC1 | O15118 | 4/20 | 0.70 |
| ▸ | RAB9A | P51151 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 4/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28601917 | 0.84 | HIF1A (1.00) | HIF1AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5216536 | 0.84 | KMT2A (0.65) | HIF1AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13210645 | 0.83 | ROCK2 (0.55) | HIF1AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13210639 | 0.83 | RAB9A (0.64) | HIF1AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1330200 | 0.81 | NPC1 (0.58) | HIF1AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1331796 | 0.81 | RAB9A (0.64) | HIF1AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8218590 | 0.81 | NPC1 (0.71) | HIF1AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL937744 | 0.81 | HIF1A (0.63) | HIF1AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3961413 | 0.80 | KMT2A (0.67) | HIF1AKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1330392 | 0.79 | RAB9A (0.60) | HIF1AKMT2ANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100204219-A1 | AROMATIC 1,4-DI-CARBOXYLAMIDES AND THEIR USE | THE GENETICS COMPANY, INC. (CH) | 2010-08-12 | — | — | US | disclosed |
| US-20100204219-A1 | AROMATIC 1,4-DI-CARBOXYLAMIDES AND THEIR USE | THE GENETICS COMPANY, INC. (CH) | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204219-A1 | AROMATIC 1,4-DI-CARBOXYLAMIDES AND THEIR USE | CBR3, CYCS, CYC1 | HIF1A 1829/4885KMT2A 2067/4885NPC1 1471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.