⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL344278 | 0.84 | — | — | |
| SCHEMBL26923746 | 0.80 | ATM (0.34) | — | |
| SCHEMBL446279 | 0.79 | — | — | |
| SCHEMBL7963081 | 0.77 | TSHR (0.39) | — | |
| SCHEMBL9836229 | 0.77 | — | — | |
| SCHEMBL320484 | 0.77 | — | — | |
| SCHEMBL320827 | 0.77 | ALDH1A1 (0.40) | — | |
| SCHEMBL444270 | 0.76 | ATM (0.54) | — | |
| SCHEMBL6895706 | 0.74 | — | — | |
| SCHEMBL9298820 | 0.74 | ALDH1A1 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4898873-A | α,α-Diaryl-4-aryl-4-hydroxyl-1-piperidinebutanamide, N-oxides and pharmaceutical use | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-02-06 | — | — | US | claimed |
| US-6313305-B1 | ANTIBIOTICS, BACTERICIDES | HOECHST MARION ROUSSEL (FR) | 2001-11-06 | — | — | US | disclosed |
| US-5936083-A | BACTERICIDES | Uclaf, Roussel (FR) | 1999-08-10 | — | — | US | disclosed |
| US-5883248-A | QUATERNARY AMMONIUM INTERMEDIATES | ROUSSEL UCLAF (FR) | 1999-03-16 | — | — | US | disclosed |
| EP-0462009-B1 | Cephalosporins having in position 3 a propenyl radical substituted by a quaternary ammonium, their process for preparation, their use as medicaments, compositions containing them and intermediates | HOECHST MARION ROUSSEL INC (FR) | 1998-10-28 | — | — | EP | disclosed |
| US-5763617-A | Cephalosporins | ROUSSEL UCLAF (FR) | 1998-06-09 | — | — | US | disclosed |
| US-5728828-A | A 3-(3-CHLORO- OR IODOPROP-1-EN-1-YL),7-(2-AMINOTHIAZOL-4-YL) ((CARBOXY)(PHENYL)METHOXYIMINO)ACETAMIDO-3-CEPHEM; GRAMNEGATIVE AND -POSITIVE BACTERIA, ESP. ANTIBIOTIC-RESISTANCE STAPHYLOCOCCUS | ROUSSEL UCLAF (FR) | 1998-03-17 | — | — | US | disclosed |
| US-5712266-A | Cephalosporins | ROUSSEL UCLAF (FR) | 1998-01-27 | — | — | US | disclosed |
| US-5710147-A | ANTIBIOTICS | ROUSSEL UCLAF (FR) | 1998-01-20 | — | — | US | disclosed |
| US-5683996-A | ISOCEPHALOSPORINS; GRAMPOSITIVE BACTERIA ESPECIALLY PENICILLIN-RESISTANT STAPHYLOCOCCUS; GRAMNEGATIVE BACTERIA, PARTICULARLY COLIFORM | ROUSSEL UCLAF (FR) | 1997-11-04 | — | — | US | disclosed |
| US-5378697-A | BACTERICIDES | ROUSSEL-UCLAF (FR) | 1995-01-03 | — | — | US | disclosed |
| US-5373001-A | Antibiotics | ROUSSEL UCLAF (FR) | 1994-12-13 | — | — | US | disclosed |
| EP-0315518-B1 | Cephalosporins having in position 3 a substituted vinyl radical, their process for preparation, their application as medicaments, compositions containing them and intermediates | ROUSSEL UCLAF (FR) | 1994-02-16 | — | — | EP | disclosed |
| US-5243043-A | Cephalosporin antibiotics and bactericides | ROUSSEL UCLAF (FR) | 1993-09-07 | — | — | US | disclosed |
| EP-0520880-A1 | Cephalosporines having a 2-thia cephem ring, process for their preparation, pharmaceutical compositions containing them, their application as medicaments and intermediates | ROUSSEL UCLAF (FR) | 1992-12-30 | — | — | EP | disclosed |
| US-5075298-A | Antibiotics | ROUSSEL UCLAF (FR) | 1991-12-24 | — | — | US | disclosed |
| EP-0462009-A1 | Cephalosporins having in position 3 a propenyl radical substituted by a quaternary ammonium, their process for preparation, their use as medicaments, compositions containing them and intermediates | ROUSSEL UCLAF (FR) | 1991-12-18 | — | — | EP | disclosed |
| US-4992431-A | Bactericides or antibiotics | ROUSSELUCLAF (FR) | 1991-02-12 | — | — | US | disclosed |
| US-4908359-A | Pharmaceuticals | Uclaf, Roussel (FR) | 1990-03-13 | — | — | US | disclosed |
| EP-0315518-A1 | Cephalosporins having in position 3 a substituted vinyl radical, their process for preparation, their application as medicaments, compositions containing them and intermediates | ROUSSEL-UCLAF (FR) | 1989-05-10 | — | — | EP | disclosed |