Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.48 |
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.48 |
| ▸ | GAA | P10253 | 6/20 | 0.48 |
| ▸ | MGAM | O43451 | 5/20 | 0.48 |
| ▸ | SI | P14410 | 5/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7691472 | 0.91 | GAA (0.53) | RAB9ANPC1SMN1; SMN2GAAMGAM | |
| SCHEMBL7689804 | 0.88 | RAB9A (0.63) | RAB9ANPC1SMN1; SMN2GAAMGAM | |
| SCHEMBL7686239 | 0.84 | GRIN1 (0.49) | RAB9ANPC1SMN1; SMN2GAAPOLB | |
| SCHEMBL8668275 | 0.83 | RAB9A (0.61) | RAB9ANPC1SMN1; SMN2GAAPOLB | |
| SCHEMBL7689249 | 0.79 | RAB9A (0.48) | RAB9ANPC1SMN1; SMN2GAAPOLB | |
| SCHEMBL7688380 | 0.78 | RAB9A (0.76) | RAB9ANPC1SMN1; SMN2GAAPOLB | |
| SCHEMBL7686249 | 0.78 | NPC1 (0.47) | RAB9ANPC1SMN1; SMN2GAATP53 | |
| SCHEMBL7689730 | 0.75 | RAB9A (0.51) | RAB9ANPC1SMN1; SMN2GAAPOLB | |
| SCHEMBL4062820 | 0.74 | MGAM (0.51) | GAAMGAMSIMGAM2TDP1 | |
| SCHEMBL4359045 | 0.73 | MGAM (0.51) | GAAMGAMSIMGAM2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255494-B1 | SUBSTITUTED BENZIMIDAZOLES USEFUL IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH EXCESS OF NEUROPEPTIDE Y (AROUND ARTERIES IN HEART, RESPIRATORY TRACT, GASTROINTESTINAL TRACT AND GENITOURINARY TRACT); ETIOLOGY OF PSYCHIATRIC DISORDERS | ELI LILLY AND COMPANY | 2001-07-03 | — | — | US | disclosed |
| EP-0871442-A1 | BENZIMIDZOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1997025041-A1 | BENZIMIDZOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-07-17 | — | — | WO | disclosed |