Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 15/20 | 0.51 |
| ▸ | GAA | P10253 | 15/20 | 0.51 |
| ▸ | SI | P14410 | 15/20 | 0.51 |
| ▸ | MGAM2 | Q2M2H8 | 15/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | CBFB | Q13951 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4359045 | 0.85 | MGAM (0.51) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL30518181 | 0.84 | DDAH1 (0.55) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL4919548 | 0.84 | DDAH1 (0.55) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL7409334 | 0.82 | MGAM (0.49) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL4346855 | 0.82 | MGAM (0.51) | MGAMGAASIMGAM2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL23497514 | 0.81 | MGAM (0.47) | MGAMGAASIMGAM2ALDH1A1 | |
| Bromide SCHEMBL844133 | 0.81 | MGAM (0.47) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL1917210 | 0.81 | MGAM (0.47) | MGAMGAASIMGAM2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7416048 | 0.81 | MGAM (0.47) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL2307747 | 0.80 | PSMB8 (0.53) | MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221309-B1 | NOVEL BENZIMIDAZOLE BASED EGFR INHIBITORS | COUNCIL SCIENT IND RES (IN) | 2019-11-13 | — | — | EP | claimed |
| US-9862712-B2 | Benzimidazole based EGFR inhibitors | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2018-01-09 | — | — | US | claimed |
| EP-3221309-A1 | NOVEL BENZIMIDAZOLE BASED EGFR INHIBITORS | Council of Scientific and Industrial Research (IN) | 2017-09-27 | — | — | EP | claimed |
| US-20170267671-A1 | NOVEL BENZIMIDAZOLE BASED EGFR INHIBITORS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-09-21 | — | — | US | claimed |
| WO-2016079763-A1 | NOVEL BENZIMIDAZOLE BASED EGFR INHIBITORS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-05-26 | — | — | WO | claimed |
| US-20220409589-A1 | CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY | GENZYME CORP (US) | 2022-12-29 | — | — | US | disclosed |
| EP-3221309-B1 | NOVEL BENZIMIDAZOLE BASED EGFR INHIBITORS | COUNCIL SCIENT IND RES (IN) | 2019-11-13 | — | — | EP | disclosed |
| US-10322111-B2 | Chemokine receptor binding heterocyclic compounds with enhanced efficacy | GENZYME CORPORATION (US) | 2019-06-18 | — | — | US | disclosed |
| CN-107759604-A | A kind of method that benzimidazole and quinoxaline derivant are catalyzed and synthesized under microwave radiation | 福建医科大学 | 2018-03-06 | — | — | CN | disclosed |
| US-9862712-B2 | Benzimidazole based EGFR inhibitors | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2018-01-09 | — | — | US | disclosed |
| EP-3221309-A1 | NOVEL BENZIMIDAZOLE BASED EGFR INHIBITORS | Council of Scientific and Industrial Research (IN) | 2017-09-27 | — | — | EP | disclosed |
| US-20170267671-A1 | NOVEL BENZIMIDAZOLE BASED EGFR INHIBITORS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-09-21 | — | — | US | disclosed |
| EP-0502106-A1 | SUBSTITUTED INDOLE-, INDENE-, PYRANOINDOLE- AND TETRAHYDROCARBAZOLE- ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA2 AND LIPOXYGENASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-09 | — | — | EP | disclosed |
| EP-0497888-A1 | SUBSTITUTED BENZOYLBENZENE-, BIPHENYL- AND 2-OXAZOLE- ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA 2? AND LIPOXYGENASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-08-12 | — | — | EP | disclosed |
| WO-1992004325-A1 | NAPHTHALENEPROPIONIC ACID DERIVATIVES AS ANTI-INFLAMMATORY/ANTIALLERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-03-19 | — | — | WO | disclosed |
| WO-1991006538-A1 | SUBSTITUTED BENZOYLBENZENE-, BIPHENYL- AND 2-OXAZOLE- ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA2 AND LIPOXYGENASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-16 | — | — | WO | disclosed |
| WO-1991006537-A2 | SUBSTITUTED INDOLE-, INDENE-, PYRANOINDOLE- AND TETRAHYDROCARBAZOLE- ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA2 AND LIPOXYGENASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-16 | — | — | WO | disclosed |
| EP-0209106-B1 | 2-(4-PYRIDYLAMINOMETHYL)-BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS | Maruishi Seiyaku Kabushiki Kaisha (JP) | 1989-10-18 | — | — | EP | disclosed |
| US-4714764-A | ENTEROVIRUS AND RHINOVIRUS | MARUISHI SEIYAKU KABUSHIKI KAISHA (JP) | 1987-12-22 | — | — | US | disclosed |
| EP-0209106-A1 | 2-(4-Pyridylaminomethyl)-benzimidazole derivatives and pharmaceutical compositions | Maruishi Seiyaku Kabushiki Kaisha (JP) | 1987-01-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267671-A1 | NOVEL BENZIMIDAZOLE BASED EGFR INHIBITORS | EGFR, ERBB4, ERBB2 | MGAM 4699/4885GAA 3066/4885SI 2054/4885 |
| US-10322111-B2 | Chemokine receptor binding heterocyclic compounds with enhanced efficacy | CCR5, CXCR4, CXCR3 | MGAM 4787/4885GAA 4869/4885SI 4462/4885 |
| US-20220409589-A1 | CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY | CCR5, CXCR4, CXCR3 | MGAM 4787/4885GAA 4869/4885SI 4462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.