Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976882 | 0.86 | HTT (0.55) | HTTTSHRKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2760109 | 0.73 | HTT (0.77) | HTTTSHRKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL951889 | 0.72 | TSHR (0.46) | HTTKDM4ETSHRKMT2ASMN1; SMN2 | |
| SCHEMBL8616990 | 0.70 | SMN1; SMN2 (0.79) | HTTKDM4ETSHRKMT2ASMN1; SMN2 | |
| SCHEMBL1455628 | 0.69 | TSHR (0.56) | HTTGAATSHRKMT2ASMN1; SMN2 | |
| SCHEMBL10272442 | 0.69 | TSHR (0.61) | TSHRKMT2ASMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL9194931 | 0.69 | HTT (0.45) | HTTKDM4EGAATSHRKMT2A | |
| SCHEMBL5274851 | 0.69 | SMN1; SMN2 (0.48) | HTTGAATSHRKMT2ASMN1; SMN2 | |
| SCHEMBL11661654 | 0.66 | MMP1 (0.46) | KDM4EKMT2AALDH1A1POLB | |
| SCHEMBL11661657 | 0.66 | MMP1 (0.46) | KDM4EKMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001007409-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | ASTRAZENECA UK LIMITED (GB) | 2001-02-01 | — | — | WO | disclosed |