Sugi Predict

Sugi Predict / Compounds / SCHEMBL7963485

SCHEMBL7963485

SCHEMBL7963485

Fc1ccc(OCc2cccc(Cl)c2)c(F)c1Cc1c[nH]c2ncccc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 1/20 0.47
▸ FGFR4 P22455 1/20 0.47
▸ MET P08581 1/20 0.47
▸ GPR84 Q9NQS5 1/20 0.46
▸ PPIF P30405 1/20 0.43
▸ PDPK1 O15530 2/20 0.41
▸ SGMS2 Q8NHU3 2/20 0.40
▸ KDM4E B2RXH2 1/20 0.40
▸ LMNA P02545 1/20 0.40
▸ MAPT P10636 1/20 0.40
▸ HPGD P15428 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ CYP3A4 P08684 1/20 0.38
▸ CYP2C19 P33261 1/20 0.38
▸ HTR1A P08908 1/20 0.38
▸ HTR2A P28223 1/20 0.38
▸ HTR7 P34969 1/20 0.38
▸ SMARCA2 P51531 1/20 0.38
▸ RHEB Q15382 1/20 0.38
▸ MRGPRX4 Q96LA9 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL412863 0.89 MET (0.58) FGFR1FGFR4METGPR84PDPK1
SCHEMBL415488 0.87 GPR84 (0.47) FGFR1FGFR4METGPR84LMNA
SCHEMBL410185 0.86 GPR84 (0.50) FGFR1FGFR4METGPR84PDPK1
SCHEMBL411594 0.83 MET (0.56) FGFR1FGFR4METGPR84PDPK1
SCHEMBL417796 0.80 CYP3A4 (0.46) METCYP3A4CYP2C19HTR1A
SCHEMBL857692 0.79 MET (0.69) FGFR1FGFR4METGPR84PDPK1
SCHEMBL415636 0.78 MET (0.51) FGFR1FGFR4METGPR84PDPK1
SCHEMBL1267619 0.77 MET (0.53) FGFR1FGFR4METGPR84PDPK1
SCHEMBL410294 0.77 KIT (0.45) METPDPK1
SCHEMBL14147083 0.76 GPR84 (0.44) FGFR1FGFR4METGPR84PDPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100249118-A1 protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents PLEXXIKON INC. 2010-09-30 — — US disclosed
US-20100249118-A1 protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents PLEXXIKON INC. 2010-09-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100249118-A1 protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents MAP4K1, MAP4K2, MAP3K1 FGFR1 531/4885FGFR4 1203/4885MET 630/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.