Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22789740 | 0.80 | MAP4K4 (0.64) | MAPK14CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL1554557 | 0.78 | MAPK14 (0.60) | MAPK14ADORA1CCNT1CCNA2CDK2 | |
| SCHEMBL5360781 | 0.77 | MAPK14 (0.42) | MAPK14CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL5353023 | 0.76 | MAPK14 (0.47) | MAPK14CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL5355304 | 0.76 | MAPK14 (0.42) | MAPK14CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL4266368 | 0.75 | ALDH1A1 (0.67) | PTGS2CA12CA9POLBMAOB | |
| SCHEMBL16105409 | 0.74 | MAPK14 (0.53) | MAPK14CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL6581932 | 0.74 | MAPK14 (0.51) | MAPK14ADORA1CCNT1CCNA2CDK2 | |
| SCHEMBL5354671 | 0.73 | MAPK14 (0.42) | MAPK14CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL28709958 | 0.73 | PTGS2 (0.64) | PTGS2CA12CA9POLBMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998425-A | CYTOKINE ANTAGONIST; ANTIARTHRITIC AGENT | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-07 | — | — | US | claimed |
| EP-0871622-A4 | — | — | 1998-10-21 | — | — | EP | claimed |
| EP-0871622-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-21 | — | — | EP | claimed |
| WO-1995031451-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-11-23 | — | — | WO | claimed |
| US-6306883-B1 | NOVEL PYRAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING A COMPOUND AND INHIBITING CYTOKINES BY A COMPOUND OF FORMULA (I) AND THE TREATMENT OF CYTOKINES MEDIATED DISEASES, | SMITHKLINE BEECHAM CORPORATION | 2001-10-23 | — | — | US | disclosed |
| US-5998425-A | CYTOKINE ANTAGONIST; ANTIARTHRITIC AGENT | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-07 | — | — | US | disclosed |