Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27010055 | 0.90 | JAK2 (0.37) | JAK2 | |
| SCHEMBL10170742 | 0.76 | GRM5 (0.30) | GRM5 | |
| SCHEMBL6124130 | 0.75 | GRM5 (0.42) | GRM5NOTUMJAK2 | |
| SCHEMBL26618597 | 0.69 | ALDH1A1 (0.36) | — | |
| SCHEMBL19164235 | 0.69 | MAPT (0.34) | — | |
| SCHEMBL22349243 | 0.68 | NOTUM (0.41) | GRM5NOTUM | |
| SCHEMBL21730189 | 0.67 | GRM5 (0.36) | GRM5NOTUM | |
| SCHEMBL19164017 | 0.66 | HRH3 (0.33) | — | |
| SCHEMBL10094132 | 0.66 | JAK2 (0.40) | GRM5JAK2 | |
| SCHEMBL14560231 | 0.66 | BMPR1B (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147476-A1 | NOVEL PDE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-12-10 | — | — | WO | disclosed |