Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 8/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975393 | 0.80 | HTT (0.45) | ARHTTSMN1; SMN2MAPTLMNA | |
| Hydrochloric Acid SCHEMBL8092772 | 0.76 | NPC1 (0.42) | HTTSMN1; SMN2MAPTLMNANPC1 | |
| Hydrochloric Acid SCHEMBL8089347 | 0.75 | MAPT (0.37) | ARHTTSMN1; SMN2MAPTLMNA | |
| Hydrochloric Acid SCHEMBL8089324 | 0.74 | MAPT (0.37) | ARHTTSMN1; SMN2MAPTLMNA | |
| SCHEMBL7964032 | 0.72 | NPC1 (0.60) | ARHTTSMN1; SMN2MAPTLMNA | |
| SCHEMBL7974426 | 0.72 | SMN1; SMN2 (0.55) | ARHTTSMN1; SMN2MAPTLMNA | |
| SCHEMBL7974431 | 0.72 | SMN1; SMN2 (0.55) | ARHTTSMN1; SMN2MAPTLMNA | |
| SCHEMBL7964015 | 0.71 | EPHX2 (0.64) | ARHTTSMN1; SMN2MAPTLMNA | |
| SCHEMBL7964004 | 0.71 | NPC1 (0.55) | ARHTTSMN1; SMN2MAPTLMNA | |
| SCHEMBL7974453 | 0.71 | NPC1 (0.50) | ARHTTSMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |