Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TYMS | P04818 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9233969 | 0.87 | BRD2 (0.52) | HTTMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8005983 | 0.83 | NPC1 (0.45) | HTTMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8413272 | 0.82 | NPC1 (0.43) | HTTMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8410247 | 0.82 | NPC1 (0.43) | HTTMAPTSMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8413072 | 0.81 | NPC1 (0.42) | HTTMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7963955 | 0.80 | AR (0.42) | HTTMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7964032 | 0.76 | NPC1 (0.60) | HTTMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7964039 | 0.76 | RAB9A (0.54) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL7964015 | 0.75 | EPHX2 (0.64) | HTTMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7964004 | 0.75 | NPC1 (0.55) | HTTMAPTSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |