Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.41 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965107 | 0.89 | SIGMAR1 (0.51) | MAPTHTR7KDM4ESIGMAR1HRH1 | |
| SCHEMBL7949605 | 0.89 | DRD2 (0.48) | SLC27A1SIGMAR1HRH1 | |
| SCHEMBL7959798 | 0.88 | DRD2 (0.47) | SLC27A1SIGMAR1HRH1 | |
| SCHEMBL7963539 | 0.88 | SIGMAR1 (0.50) | MAPTHTR7KDM4ESIGMAR1HRH1 | |
| Hydrochloric Acid SCHEMBL7960917 | 0.87 | SIGMAR1 (0.49) | MAPTHTR7KDM4ESIGMAR1HRH1 | |
| Hydrochloric Acid SCHEMBL7959877 | 0.84 | DRD3 (0.51) | HTR7SIGMAR1HRH1 | |
| SCHEMBL7961291 | 0.81 | SIGMAR1 (0.40) | ADRA1DADRA1AADRA1BTSHRALDH1A1 | |
| SCHEMBL7959657 | 0.79 | SIGMAR1 (0.51) | HTR7SIGMAR1 | |
| SCHEMBL5776790 | 0.78 | MAPT (0.45) | MAPTNPSR1HTR7SLC27A1ADRA1D | |
| SCHEMBL5775439 | 0.78 | MAPT (0.45) | MAPTNPSR1HTR7SLC27A1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |