Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962951 | 0.90 | CYP11B2 (0.37) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL8327786 | 0.90 | CYP11B2 (0.37) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7962850 | 0.89 | MKNK1 (0.41) | CYP19A1CYP11B1CYP11B2EGFRFGFR1 | |
| SCHEMBL7963232 | 0.89 | NR4A2 (0.39) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7963752 | 0.88 | SLC2A1 (0.39) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7964071 | 0.85 | CYP11B2 (0.39) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7965769 | 0.85 | CFTR (0.41) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7967142 | 0.79 | IDO1 (0.34) | MEN1KMT2AABL1 | |
| SCHEMBL7961242 | 0.79 | IDO1 (0.34) | MEN1KMT2ATUBB4ATUBBTUBA3C | |
| SCHEMBL7963276 | 0.79 | CYP11B2 (0.39) | ALDH1A1CYP11B1CYP11B2MAPK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |