Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 10/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961877 | 0.89 | CYP11B2 (0.40) | CYP11B2CYP11B1CYP19A1CYP3A4ADORA1 | |
| SCHEMBL8329319 | 0.87 | CYP11B2 (0.38) | CYP11B2CYP11B1ADORA2AADORA1KMT2A | |
| SCHEMBL7965727 | 0.86 | MKNK1 (0.38) | CYP11B2CYP11B1ADORA2AADORA1 | |
| SCHEMBL7963752 | 0.86 | SLC2A1 (0.39) | CYP11B2CYP11B1CYP19A1CYP3A4GABRA1 | |
| SCHEMBL7964018 | 0.85 | GABRA1 (0.40) | CYP11B2CYP11B1CYP19A1CYP3A4GABRA1 | |
| SCHEMBL7963232 | 0.85 | NR4A2 (0.39) | CYP11B2CYP11B1CYP19A1HTR2AHTR2C | |
| SCHEMBL7965769 | 0.83 | CFTR (0.41) | CYP11B2CYP11B1CYP19A1CYP3A4HTR2A | |
| SCHEMBL7962786 | 0.82 | CYP11B2 (0.41) | CYP11B2CYP11B1CYP19A1CYP3A4ADORA2A | |
| SCHEMBL7967763 | 0.81 | HCRTR1 (0.35) | CYP11B2HTR2AHTR2CMEN1KMT2A | |
| SCHEMBL7952832 | 0.81 | HCRTR1 (0.34) | HTR2AHTR2CMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |