Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.46 |
| ▸ | CTSS | P25774 | 4/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10463735 | 0.77 | CTSK (0.49) | CTSKCTSSMMP8MAPTSYK | |
| SCHEMBL31477126 | 0.77 | CTSK (0.49) | CTSKCTSSMMP8MAPTSYK | |
| SCHEMBL31503086 | 0.76 | CTSK (0.48) | CTSKCTSSMMP8MAPTCTSL | |
| SCHEMBL31477667 | 0.76 | CTSK (0.48) | CTSKCTSSMMP8MAPTCTSL | |
| SCHEMBL31503119 | 0.76 | CTSK (0.48) | CTSKCTSSMMP8MAPTCTSL | |
| SCHEMBL27833801 | 0.76 | CTSK (0.62) | CTSKCTSSMMP8MAPTSYK | |
| SCHEMBL10240502 | 0.76 | CTSK (0.62) | CTSKCTSSMMP8MAPTSYK | |
| SCHEMBL29005173 | 0.74 | ALDH1A1 (0.54) | CTSKCTSSMAPT | |
| SCHEMBL561366 | 0.73 | CYP1A2 (0.55) | CTSKCTSSMAPT | |
| SCHEMBL21603014 | 0.72 | CYP1A2 (0.49) | CTSKCTSSMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271238-B1 | USEFUL IN TREATING AND PREVENTING DISEASES INVOLVING CHYMOTRYPSIN TYPE PROTEASES WHICH ARE RELATED TO ASTHMA, ALLERGY, INFLAMMATIONS, RHEUMATISM, HYPERTENSION, HEART FAILURE, MYOCARDIAL INFARCTION, AND CARDIAC HYPERTROPHY | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-08-07 | — | — | US | disclosed |
| EP-0936216-A1 | NOVEL ACETAMIDE DERIVATIVES AND PROTEASE INHIBITORS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1999-08-18 | — | — | EP | disclosed |