Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 13/20 | 0.76 |
| ▸ | ICMT | O60725 | 1/20 | 0.47 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.47 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775439 | 0.90 | PLA2G2A (0.61) | PLA2G2AL3MBTL1ADORA1CHRM1 | |
| SCHEMBL7961599 | 0.81 | PLA2G2A (0.76) | PLA2G2AICMT | |
| SCHEMBL7965269 | 0.79 | PLA2G2A (0.60) | PLA2G2AICMTPLA2G10 | |
| SCHEMBL6775064 | 0.78 | PLA2G2A (0.65) | PLA2G2AICMT | |
| SCHEMBL14819907 | 0.77 | ADORA1 (0.74) | PLA2G2AL3MBTL1ADORA1 | |
| SCHEMBL6775267 | 0.76 | PLA2G2A (0.51) | PLA2G2AICMTL3MBTL1CHRM1 | |
| SCHEMBL6775272 | 0.76 | PLA2G2A (0.51) | PLA2G2AICMTL3MBTL1CHRM1 | |
| SCHEMBL1607281 | 0.74 | MAPT (0.53) | PLA2G2A | |
| SCHEMBL7962736 | 0.74 | PLA2G2A (1.00) | PLA2G2APLA2G10PLA2G1BPLA2G5PLA2G2E | |
| SCHEMBL30914311 | 0.73 | MAPT (0.55) | ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6252084-B1 | THERAPY FOR SEPSIS SHOCK | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0620215-B1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | LILLY CO ELI (US) | 1999-08-18 | — | — | EP | disclosed |
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0620215-A1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |