SCHEMBL7964459

SCHEMBL7964459

Cc1ccc(C(=O)O)cc1CC1CCCC=C1c1nc(-c2ccccc2)c(-c2ccccc2)o1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 5/20 0.73
PTGIR P43119 4/20 0.73
PTGER1 P34995 1/20 0.73
PTGER3 P43115 1/20 0.56
FABP4 P15090 2/20 0.38
FABP3 P05413 1/20 0.38
KDM4E B2RXH2 3/20 0.36
HPGD P15428 3/20 0.36
TDP1 Q9NUW8 3/20 0.36
LMNA P02545 2/20 0.36
HTT P42858 2/20 0.36
NR4A2 P43354 5/20 0.36
ALDH1A1 P00352 2/20 0.35
CYP1A2 P05177 2/20 0.35
CYP3A4 P08684 2/20 0.35
CYP2D6 P10635 2/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
HSD17B10 Q99714 1/20 0.35
MAPT P10636 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7961287 0.91 PTGER4 (0.61) PTGER4PTGIRPTGER1PTGER3FABP4
SCHEMBL7488841 0.88 PTGER4 (0.61) PTGER4PTGIRPTGER1PTGER3FABP4
SCHEMBL8551042 0.87 PTGIR (0.60) PTGER4PTGIRPTGER1PTGER3FABP4
SCHEMBL7494436 0.85 PTGIR (0.65) PTGER4PTGIRPTGER1PTGER3FABP4
SCHEMBL7957721 0.85 PTGER4 (0.81) PTGER4PTGIRPTGER1PTGER3FABP4
SCHEMBL7960451 0.85 PTGER4 (0.81) PTGER4PTGIRPTGER1PTGER3FABP4
SCHEMBL7970546 0.85 PTGER4 (0.72) PTGER4PTGIRPTGER1PTGER3FABP4
SCHEMBL8551039 0.85 PTGIR (0.57) PTGER4PTGIRPTGER1PTGER3FABP4
SCHEMBL7964078 0.85 PTGIR (0.74) PTGER4PTGIRPTGER1PTGER3FABP4
SCHEMBL7489516 0.85 PTGER4 (0.56) PTGER4PTGIRPTGER1PTGER3FABP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6245790-B1 ANTIINFLAMMATORY AGENTS; GASTROINTESTINAL DISORDERS; SKN DISORDERS; BONE DISORDERS; MUSCLE RELAXANTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-06-12 US disclosed
EP-0989975-A1 OXAZOLE COMPOUNDS USEFUL AS PGE2 AGONISTS AND ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-04-05 EP disclosed
WO-2000016760-A2 NEW USE OF PROSTAGLANDIN E2 ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-03-30 WO disclosed
WO-1998055468-A1 OXAZOLE COMPOUNDS USEFUL AS PGE2 AGONISTS AND ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-12-10 WO disclosed