Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | TP53 | P04637 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3133660 | 1.00 | ALDH1A1 (0.59) | ALDH1A1TSHRTP53SMN1; SMN2HIF1A | |
| SCHEMBL7964625 | 1.00 | ALDH1A1 (0.59) | ALDH1A1TSHRTP53SMN1; SMN2HIF1A | |
| SCHEMBL3142670 | 0.97 | SMN1; SMN2 (0.59) | ALDH1A1TSHRTP53SMN1; SMN2HIF1A | |
| SCHEMBL1495909 | 0.80 | GRM2 (0.50) | ALDH1A1TSHRTP53SMN1; SMN2HIF1A | |
| SCHEMBL1495907 | 0.80 | GRM2 (0.50) | ALDH1A1TSHRTP53SMN1; SMN2HIF1A | |
| SCHEMBL7777400 | 0.79 | MAOB (0.58) | ALDH1A1TSHRTP53SMN1; SMN2HIF1A | |
| SCHEMBL11875425 | 0.79 | ALDH1A1 (0.49) | ALDH1A1TSHRTP53SMN1; SMN2HIF1A | |
| SCHEMBL1715242 | 0.78 | ALDH1A1 (0.71) | ALDH1A1TSHRTP53SMN1; SMN2HIF1A | |
| SCHEMBL20677146 | 0.78 | TDP1 (0.79) | ALDH1A1TSHRTP53SMN1; SMN2HIF1A | |
| SCHEMBL21094081 | 0.78 | TDP1 (0.79) | ALDH1A1TSHRTP53SMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006082-A2 | TREATMENT OF ANXIETY DISORDERS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |