Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 17/20 | 0.58 |
| ▸ | MAOA | P21397 | 15/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11102770 | 0.92 | MAOB (0.53) | MAOBMAOAALDH1A1TP53CYP3A4 | |
| SCHEMBL15818207 | 0.83 | MAOB (0.60) | MAOBMAOA | |
| SCHEMBL3142670 | 0.82 | SMN1; SMN2 (0.59) | ALDH1A1TP53CYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL4290272 | 0.80 | GPR84 (0.60) | SMN1; SMN2 | |
| SCHEMBL17361548 | 0.80 | MAOB (0.54) | MAOBMAOA | |
| SCHEMBL4290278 | 0.80 | GPR84 (0.60) | SMN1; SMN2 | |
| SCHEMBL11099412 | 0.80 | ALDH1A1 (0.53) | MAOBMAOAALDH1A1TP53CYP3A4 | |
| SCHEMBL28010014 | 0.79 | ALDH1A1 (0.59) | ALDH1A1TP53CYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL7964624 | 0.79 | ALDH1A1 (0.59) | ALDH1A1TP53CYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL7964625 | 0.79 | ALDH1A1 (0.59) | ALDH1A1TP53CYP3A4TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574906-B1 | Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing the same | NISSHIN FLOUR MILLING CO (JP) | 2001-08-22 | — | — | EP | disclosed |
| US-5380724-A | Inhibitors of lipid peroxidation | GYOGYSZERKUTATO INTEZET KFT (HU) | 1995-01-10 | — | — | US | disclosed |
| EP-0574906-A2 | Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing the same | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1993-12-22 | — | — | EP | disclosed |