Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PPID | Q08752 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PPIB | P23284 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417094 | 0.83 | GAA (0.44) | GAAEPHX2MGAMSIMGAM2 | |
| SCHEMBL2482646 | 0.81 | GAA (0.59) | GAAEPHX2MGAMSIMGAM2 | |
| SCHEMBL13367965 | 0.80 | EPHX1 (0.48) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27762950 | 0.79 | GAA (0.57) | GAAEPHX2MGAMSIMGAM2 | |
| SCHEMBL206033 | 0.78 | PTGIR (0.45) | ALDH1A1 | |
| SCHEMBL12223164 | 0.77 | MEN1 (0.50) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL13967719 | 0.76 | EPHX1 (0.42) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9404556 | 0.75 | GAA (0.57) | GAAEPHX2MGAMSIMGAM2 | |
| SCHEMBL8250958 | 0.75 | PTGIR (0.37) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7425848 | 0.75 | EPHX1 (0.57) | GAAEPHX2MGAMSIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211228-B1 | COMPOUNDS WITH AMINO, GUANIDINO AND AMIDINO HETEROCYCLIC COMPOUNDS | AXYS PHARMACEUTICALS, INC | 2001-04-03 | — | — | US | disclosed |
| US-6022969-A | Compositions and methods for treating mast-cell mediated conditions | AXYS PHARMACEUTICALS, INC. (US) | 2000-02-08 | — | — | US | disclosed |