Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | CACNA1G | O43497 | 6/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
| ▸ | SCN1A | P35498 | 3/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965753 | 0.91 | KMT2A (0.50) | PRMT5WDR77KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL7953359 | 0.91 | PRMT5 (0.45) | CYP2D6PRMT5WDR77L3MBTL1SMN1; SMN2 | |
| SCHEMBL7969553 | 0.89 | L3MBTL1 (0.55) | CYP2D6PRMT5WDR77KMT2AL3MBTL1 | |
| SCHEMBL7953344 | 0.88 | KDM4E (0.53) | CYP2D6CACNA1GPRMT5WDR77KMT2A | |
| SCHEMBL7953454 | 0.88 | PRMT5 (0.47) | CYP2D6PRMT5WDR77L3MBTL1SMN1; SMN2 | |
| SCHEMBL7969310 | 0.88 | L3MBTL1 (0.51) | CYP2D6PRMT5WDR77KMT2AL3MBTL1 | |
| SCHEMBL7965174 | 0.88 | KMT2A (0.52) | CACNA1GKCNH2PRMT5WDR77KMT2A | |
| SCHEMBL7966950 | 0.88 | TSHR (0.56) | CYP2D6PRMT5WDR77KMT2AL3MBTL1 | |
| SCHEMBL27193282 | 0.88 | SMN1; SMN2 (0.57) | PRMT5WDR77SMN1; SMN2 | |
| SCHEMBL7200720 | 0.88 | SMN1; SMN2 (0.57) | PRMT5WDR77SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |