Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964770 | 0.93 | MAP3K7 (0.33) | ADRA1DADRA1AADRA1BMAP3K7HDAC3 | |
| SCHEMBL7966512 | 0.93 | BTK (0.34) | PTGESMAP3K7HDAC3BRD4HDAC4 | |
| SCHEMBL7482003 | 0.93 | MAP3K7 (0.33) | MAP3K7KMT2AHDAC3BRD4HDAC4 | |
| SCHEMBL7965069 | 0.92 | LMNA (0.36) | PTGESADRA1DADRA1AADRA1BMAP3K7 | |
| SCHEMBL7955266 | 0.92 | MAP3K7 (0.31) | MAP3K7HDAC3BRD4HDAC4HDAC1 | |
| SCHEMBL7966521 | 0.92 | MAP3K7 (0.33) | MAP3K7KMT2AHDAC3BRD4HDAC4 | |
| SCHEMBL7964677 | 0.92 | HDAC3 (0.34) | PTGESADRA1DADRA1AADRA1BMAP3K7 | |
| SCHEMBL7480014 | 0.92 | MAP3K7 (0.32) | MAP3K7HDAC3BRD4HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL7966276 | 0.92 | LMNA (0.36) | PTGESADRA1DADRA1AADRA1BMAP3K7 | |
| SCHEMBL7966817 | 0.91 | HDAC3 (0.33) | PTGESADRA1DADRA1AADRA1BMAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |