Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7966276 | 0.99 | LMNA (0.36) | LMNATP53AVPR2AVPR1APTGES | |
| SCHEMBL7480849 | 0.94 | AVPR2 (0.35) | LMNATP53AVPR2AVPR1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7481449 | 0.93 | AVPR2 (0.35) | LMNATP53AVPR2AVPR1AAVPR1B | |
| SCHEMBL7970925 | 0.93 | AVPR2 (0.38) | LMNATP53AVPR2AVPR1APTGES | |
| Dimethylamine SCHEMBL7972125 | 0.93 | AVPR2 (0.35) | LMNATP53AVPR2AVPR1AALDH1A1 | |
| SCHEMBL7964762 | 0.93 | AVPR2 (0.37) | LMNATP53AVPR2AVPR1AALDH1A1 | |
| SCHEMBL7965063 | 0.92 | PTGES (0.34) | PTGESMAPK1SMN1; SMN2USP2ADRA1D | |
| Hydrochloric Acid SCHEMBL7962267 | 0.92 | AVPR2 (0.37) | LMNATP53AVPR2AVPR1APTGES | |
| SCHEMBL7962954 | 0.92 | AVPR2 (0.34) | LMNATP53AVPR2AVPR1AAVPR1B | |
| Dimethylamine SCHEMBL7975691 | 0.92 | AVPR2 (0.34) | LMNATP53AVPR2AVPR1AAVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |