Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.50 |
| ▸ | PDE6C | P51160 | 2/20 | 0.44 |
| ▸ | PDE6D | O43924 | 1/20 | 0.44 |
| ▸ | PDE6A | P16499 | 1/20 | 0.44 |
| ▸ | PDE6G | P18545 | 1/20 | 0.44 |
| ▸ | PDE6B | P35913 | 1/20 | 0.44 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.44 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL7965337 | 0.92 | PDE5A (0.43) | PDE5APDE6CPDE6DPDE6APDE6G | |
| Sulfuric Acid SCHEMBL7959517 | 0.87 | PDE5A (0.51) | PDE5APDE6CPDE6DPDE6APDE6G | |
| Sulfuric Acid SCHEMBL7718120 | 0.84 | PDE5A (0.56) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL7959312 | 0.82 | PDE5A (0.51) | PDE5APDE6CPDE6DPDE6APDE6G | |
| Sulfuric Acid SCHEMBL7961340 | 0.81 | PDE5A (0.44) | PDE5APDE6CPDE6DPDE6APDE6G | |
| Sulfuric Acid SCHEMBL7960505 | 0.81 | PDE5A (0.52) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL7965295 | 0.81 | PDE5A (0.55) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL7029661 | 0.78 | PDE5A (0.62) | PDE5APDE6CPDE6DPDE6APDE6G | |
| Sulfuric Acid SCHEMBL7965325 | 0.77 | CRHR1 (0.36) | PDE5A | |
| SCHEMBL11629882 | 0.75 | KDM4E (0.47) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| EP-0352960-B1 | Purine compounds, process for their preparation and pharmaceutical compositions | SMITH KLINE FRENCH LAB (GB) | 1994-10-26 | — | — | EP | disclosed |
| US-5073559-A | 2-Substituted purinone having phosphodiesterase inhibitory activity | SMITH KLINE & FRENCH LABORATORIES, LTD. (GB) | 1991-12-17 | — | — | US | disclosed |
| EP-0352960-A2 | Purine compounds, process for their preparation and pharmaceutical compositions | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-01-31 | — | — | EP | disclosed |