Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.40 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7969767 | 0.99 | KDM4E (0.40) | KDM4EAVPR2AVPR1AAVPR1BALDH1A1 | |
| SCHEMBL7966271 | 0.91 | AVPR2 (0.42) | AVPR2AVPR1AAVPR1BALDH1A1SMN1; SMN2 | |
| SCHEMBL7967027 | 0.91 | MAPT (0.41) | KDM4EAVPR2AVPR1AAVPR1BALDH1A1 | |
| SCHEMBL7967316 | 0.91 | AVPR2 (0.40) | AVPR2AVPR1AAVPR1BTP53 | |
| Hydrochloric Acid SCHEMBL7966075 | 0.90 | AVPR2 (0.40) | AVPR2AVPR1AAVPR1BTP53 | |
| Hydrochloric Acid SCHEMBL7480504 | 0.90 | MAPT (0.40) | KDM4EAVPR2AVPR1AAVPR1BALDH1A1 | |
| SCHEMBL7969061 | 0.90 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL7966120 | 0.89 | ALDH1A1 (0.42) | AVPR2AVPR1AAVPR1BALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL7954426 | 0.89 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BALDH1A1SMN1; SMN2 | |
| SCHEMBL7961810 | 0.88 | AVPR2 (0.39) | AVPR2AVPR1AAVPR1BALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |