Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 4/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.39 |
| ▸ | AVPR1B | P47901 | 3/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7964094 | 0.99 | AVPR2 (0.39) | AVPR2AVPR1AAVPR1BHTR4KMT2A | |
| SCHEMBL7969478 | 0.92 | ABCB1 (0.34) | AVPR2AVPR1AAVPR1BKMT2AABCB1 | |
| Hydrochloric Acid SCHEMBL7966120 | 0.90 | ALDH1A1 (0.42) | AVPR2AVPR1AAVPR1BKMT2AABCB1 | |
| SCHEMBL7967027 | 0.89 | MAPT (0.41) | AVPR2AVPR1AAVPR1BABCB1ABCG2 | |
| SCHEMBL7967316 | 0.89 | AVPR2 (0.40) | AVPR2AVPR1AAVPR1BABCB1ABCG2 | |
| SCHEMBL7966271 | 0.89 | AVPR2 (0.42) | AVPR2AVPR1AAVPR1BKMT2AABCB1 | |
| Hydrochloric Acid SCHEMBL7480504 | 0.89 | MAPT (0.40) | AVPR2AVPR1AAVPR1BABCB1ABCG2 | |
| Hydrochloric Acid SCHEMBL7966075 | 0.89 | AVPR2 (0.40) | AVPR2AVPR1AAVPR1BABCB1ABCG2 | |
| SCHEMBL7965349 | 0.88 | KDM4E (0.40) | AVPR2AVPR1AAVPR1BKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL7969767 | 0.88 | KDM4E (0.40) | AVPR2AVPR1AAVPR1BKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |