Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961052 | 0.86 | MTNR1A (0.39) | MAPTALDH1A1POLBL3MBTL1RAB9A | |
| SCHEMBL11628940 | 0.82 | LMNA (0.42) | MAPTALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4697925 | 0.80 | MTNR1A (0.41) | MAPTALDH1A1POLBL3MBTL1CYP1A2 | |
| SCHEMBL7962857 | 0.80 | MTNR1A (0.41) | MAPTALDH1A1POLBL3MBTL1ATM | |
| SCHEMBL7963098 | 0.79 | HTR2C (0.40) | MAPTALDH1A1POLBL3MBTL1RAB9A | |
| SCHEMBL11630789 | 0.78 | LMNA (0.48) | MAPTALDH1A1L3MBTL1CYP1A2TSHR | |
| SCHEMBL7950395 | 0.78 | PTGER1 (0.42) | MAPTALDH1A1L3MBTL1RAB9ATSHR | |
| SCHEMBL14974921 | 0.78 | CYP1A2 (0.53) | MAPTALDH1A1L3MBTL1RAB9ACYP1A2 | |
| Hydrochloric Acid SCHEMBL7960837 | 0.78 | MAPT (0.43) | MAPTALDH1A1POLBGPR55RAB9A | |
| SCHEMBL23267707 | 0.74 | SMN1; SMN2 (0.56) | MAPTALDH1A1POLBGPR55L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| EP-0352960-B1 | Purine compounds, process for their preparation and pharmaceutical compositions | SMITH KLINE FRENCH LAB (GB) | 1994-10-26 | — | — | EP | disclosed |
| US-5073559-A | 2-Substituted purinone having phosphodiesterase inhibitory activity | SMITH KLINE & FRENCH LABORATORIES, LTD. (GB) | 1991-12-17 | — | — | US | disclosed |
| EP-0352960-A2 | Purine compounds, process for their preparation and pharmaceutical compositions | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-01-31 | — | — | EP | disclosed |