Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 12/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 11/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.42 |
| ▸ | HTR6 | P50406 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967657 | 0.77 | SLC6A2 (0.44) | HTR2CSLC6A2SLC6A4IKBKBHTR1A | |
| SCHEMBL5669748 | 0.76 | SLC6A2 (0.68) | HTR2CSLC6A2SLC6A4HTR1ASLC6A3 | |
| SCHEMBL7967857 | 0.71 | PDE5A (0.45) | HTR2CSLC6A2SLC6A4IKBKBHTR1A | |
| SCHEMBL7963691 | 0.71 | JUND (0.41) | HTR2CSLC6A2SLC6A4IKBKBHTR1A | |
| Hydrochloric Acid SCHEMBL15141019 | 0.70 | SLC6A2 (0.54) | HTR2CSLC6A2SLC6A4HTR1ASLC6A3 | |
| SCHEMBL30735834 | 0.70 | HTR2C (0.49) | HTR2CSLC6A2SLC6A4HTR1ASLC6A3 | |
| SCHEMBL7963921 | 0.70 | HTR2C (0.49) | HTR2CSLC6A2SLC6A4HTR1ASLC6A3 | |
| SCHEMBL5937352 | 0.70 | HTR6 (0.48) | HTR2CSLC6A2SLC6A4IKBKBHTR1A | |
| SCHEMBL6709469 | 0.70 | SLC6A2 (0.59) | HTR2CSLC6A2SLC6A4IKBKBHTR1A | |
| SCHEMBL6709239 | 0.69 | HTR6 (0.44) | HTR2CSLC6A2SLC6A4IKBKBHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |