Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.44 |
| ▸ | HTR1A | P08908 | 9/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24716111 | 0.87 | HTR2C (0.56) | SLC6A2SLC6A4HTR1ASLC6A3HTR2C | |
| SCHEMBL30626631 | 0.87 | HTR2C (0.56) | SLC6A2SLC6A4HTR1ASLC6A3HTR2C | |
| SCHEMBL7965386 | 0.77 | HTR2C (0.43) | SLC6A2SLC6A4HTR1ASLC6A3HTR2C | |
| SCHEMBL5669748 | 0.76 | SLC6A2 (0.68) | SLC6A2SLC6A4HTR1ASLC6A3HTR2C | |
| SCHEMBL25256999 | 0.74 | HTR1A (0.51) | SLC6A2SLC6A4HTR1ASLC6A3HTR2C | |
| SCHEMBL24715878 | 0.73 | HTR1A (0.50) | SLC6A2SLC6A4HTR1ASLC6A3HTR2C | |
| SCHEMBL7966174 | 0.72 | PARP1 (0.54) | IKBKB | |
| SCHEMBL4014492 | 0.72 | SLC6A2 (0.77) | SLC6A2SLC6A4HTR1ASLC6A3HTR2C | |
| SCHEMBL19297190 | 0.71 | HTR1A (0.51) | SLC6A2SLC6A4HTR1ASLC6A3HTR2C | |
| SCHEMBL30735991 | 0.71 | HTR1A (0.51) | SLC6A2SLC6A4HTR1ASLC6A3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |