Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 17/20 | 0.47 |
| ▸ | GABRD | O14764 | 17/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 17/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 17/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 17/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 17/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 17/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 17/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 17/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 17/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 17/20 | 0.47 |
| ▸ | GABRE | P78334 | 17/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 17/20 | 0.47 |
| ▸ | GABRG1 | Q8N1C3 | 17/20 | 0.47 |
| ▸ | GABRG3 | Q99928 | 17/20 | 0.47 |
| ▸ | GABRQ | Q9UN88 | 17/20 | 0.47 |
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | CCND1 | P24385 | 2/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL7965435 | 0.88 | GABRP (0.46) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7961966 | 0.76 | CDK4 (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7953286 | 0.71 | CDK4 (0.46) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7577957 | 0.68 | CRHR1 (0.54) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7969123 | 0.66 | CDK4 (0.67) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7962198 | 0.65 | CDK4 (0.50) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6928418 | 0.65 | GABRP (1.00) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7961465 | 0.65 | CRHR1 (0.48) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7965698 | 0.65 | CDK4 (0.47) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7962588 | 0.64 | CDK4 (0.62) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218397-B1 | FOR THERAPY OF STRESS-RELATED ILLNESSES, SUCH AS STRESS-INDUCED DEPRESSION, ANXIETY, AND HEADACHE; ABDOMINAL BOWEL SYNDROME; INFLAMMATORY DISEASES; IMMUNE SUPPRESSION; ALZHEIMER'S DISEASE; GASTRONINTESTINAL DISEASES | PFIZER INC | 2001-04-17 | — | — | US | disclosed |
| EP-0674642-B1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1994013677-A1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |