Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 18/20 | 0.56 |
| ▸ | CCND1 | P24385 | 18/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 10/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.56 |
| ▸ | CDK2 | P24941 | 10/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.56 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953100 | 0.83 | CDK4 (0.63) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7969123 | 0.81 | CDK4 (0.67) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7962588 | 0.77 | CDK4 (0.62) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7961966 | 0.74 | CDK4 (0.59) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7963437 | 0.74 | CDK4 (0.48) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7965911 | 0.73 | CRHR1 (0.63) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL12856393 | 0.73 | CDK4 (0.58) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8113413 | 0.71 | CDK4 (0.58) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7965183 | 0.69 | CDK4 (0.60) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7965661 | 0.69 | CDK4 (0.62) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218397-B1 | FOR THERAPY OF STRESS-RELATED ILLNESSES, SUCH AS STRESS-INDUCED DEPRESSION, ANXIETY, AND HEADACHE; ABDOMINAL BOWEL SYNDROME; INFLAMMATORY DISEASES; IMMUNE SUPPRESSION; ALZHEIMER'S DISEASE; GASTRONINTESTINAL DISEASES | PFIZER INC | 2001-04-17 | — | — | US | disclosed |
| WO-1994013677-A1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |