Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 8/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965699 | 1.00 | IDO1 (0.52) | IDO1TAAR1ALDH1A1TACR1PARP10 | |
| SCHEMBL7964819 | 0.79 | IDO1 (0.52) | IDO1TAAR1ALDH1A1TACR1MAOB | |
| SCHEMBL7955669 | 0.79 | IDO1 (0.52) | IDO1TAAR1ALDH1A1TACR1PARP10 | |
| SCHEMBL7955676 | 0.79 | IDO1 (0.52) | IDO1TAAR1ALDH1A1TACR1PARP10 | |
| SCHEMBL7964814 | 0.79 | IDO1 (0.52) | IDO1TAAR1ALDH1A1TACR1MAOB | |
| SCHEMBL7956663 | 0.77 | IDO1 (0.54) | IDO1TAAR1ALDH1A1TACR1MAPT | |
| SCHEMBL3865796 | 0.77 | IDO1 (0.67) | IDO1TAAR1ALDH1A1PARP10MAPT | |
| SCHEMBL7965700 | 0.76 | TACR1 (0.59) | IDO1TACR1 | |
| SCHEMBL7967707 | 0.76 | TACR1 (0.59) | IDO1TACR1 | |
| SCHEMBL2781643 | 0.76 | TACR1 (0.59) | IDO1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274715-B1 | SEMISYNTHETIC MACROLIDES, USEFUL IN BACTERIAL INFECTIONS TREATMENT AND PREVENTION, HAS LESS POTENTIAL FOR DEVELOPING RESISTANCE, IMPROVED OR MODIFIED PROFILES OF DESIRED GRAM-NEGATIVE ACTIVITY | ABBOTT LABORATORIES | 2001-08-14 | — | — | US | disclosed |
| EP-0961776-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | Abbott Laboratories (US) | 1999-12-08 | — | — | EP | disclosed |
| WO-1998030574-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1998-07-16 | — | — | WO | disclosed |